Research Article
Received: 2022-04-22 | Revised:2022-05-25 | Accepted: 2022-06-07 | Published: 2022-07-07
Pages: 37-46
DOI: https://doi.org/10.56717/jpp.2022.v01i01.005
Abstract
In traditional medicine, Holigarna
caustica, also known as "Borola" or "Katebel" in
Bangladesh, is used to cure tumors, malignancies, skin disorders, obesity,
inflammation, eye irritation, and arthritis. The purpose of this study was to
identify the bioactive phytochemicals in this plant that are responsible for
the analgesic effect using computational models such as in silico ADME/T and
molecular docking studies. Glide of Schrödinger Maestro (version 10.1) was used
to perform the molecular docking investigation, whereas SwissADME was employed
to determine the pharmacokinetic properties of this plant. Our computational
analysis suggested that a total of eighteen phytocompounds may be responsible
for the plant's analgesic effects, all of which were proven to be safe during
the ADME/T study and should be investigated further in experimental
models.
Abstract Keywords
Holigarna caustica, pain, analgesic, ADME/T and molecular docking study
This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Abstract
In traditional medicine, Holigarna
caustica, also known as "Borola" or "Katebel" in
Bangladesh, is used to cure tumors, malignancies, skin disorders, obesity,
inflammation, eye irritation, and arthritis. The purpose of this study was to
identify the bioactive phytochemicals in this plant that are responsible for
the analgesic effect using computational models such as in silico ADME/T and
molecular docking studies. Glide of Schrödinger Maestro (version 10.1) was used
to perform the molecular docking investigation, whereas SwissADME was employed
to determine the pharmacokinetic properties of this plant. Our computational
analysis suggested that a total of eighteen phytocompounds may be responsible
for the plant's analgesic effects, all of which were proven to be safe during
the ADME/T study and should be investigated further in experimental
models.
Abstract Keywords
Holigarna caustica, pain, analgesic, ADME/T and molecular docking study
This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Editor-in-Chief
This work is licensed under the
Creative Commons Attribution 4.0
License.(CC BY-NC 4.0).