Research Article
Received: 2022-06-30 | Revised:2022-06-25 | Accepted: 2022-06-28 | Published: 2022-06-28
Pages: 19-29
DOI: https://doi.org/10.56717/jpp.2022.v01i01.003
Abstract
Phyllanthus
reticulatus Poir has long been used in the
traditional medications for the treatment of various human diseases most
notably diarrhoea, asthma, diabetes and inflammation. Several chromatographic techniques
were used to isolate the main active constituents from different parts of the
plants using different solvents. Over the last few decades, 57 compounds have
been isolated and identified from the P.
reticulatus including 12 terpenoids, 4 steroids, 7 flavonoids, 8
phenolics, 8 lignins, 8 tannins, 5 megastigmane glycosides, 3 diterpenoids, 1 purine derivative, 2 acid
deravetives and 1 fatty alcohol. This
review provided a comprehensive overview of the phytochemistry of P. reticulatus based
on the unified review of literature. The review suggests for further avenues of research on the phytochemistry of P. reticulatus to
isolate and decipher the unidentified lead compounds for future pharmaceutical applications.
Abstract Keywords
Friedelin, flavonoids, lignin megastigmane, Phyllanthus reticulatus, phytochemistry, terpenoids,
tannin, steroids.
References
1. Schmelzer, G.H.; Gurib-Fakim, A. Medicinal plants; Prota, 2008; Vol. 11; ISBN 9057822040.
2. Jamal, A.K.;
Yaacob, W.A.; Din, L.B. A chemical study on Phyllanthus
reticulatus. J. Phys. Sci. 2008, 19, 45–50.
3. Kritikar, K.R.;
Basu, B.D. Indian medicinal plants. Dehradun: International Book
Distributors, .; 2003;
4. Akhter, S.; Simom
Hasan, M.; Hasan, M.; Begum, Y. Investigation of in vivo analgesic and
anti-inflammatory activities of methanol extracts of Phyllanthus reticulatus and Mimosa pigra. J. Pharmacog.
Phytochem 2018, 7, 2378–2385.
5. Maruthappan, V.;
Shree, S. A report on the antioxidant activity of the powder of the entire
plant of Phyllanthus reticulatus
Poir. Int. J. Green Pharm. 2010, 4.
6. Kumar, S.; Kumar,
D.; Deshmuk, R.R.; Lokhande, P.D.; More, S.N.; Rangari, V.D. Antidiabetic
potential of Phyllanthus reticulatus
in alloxan-induced diabetic mice. Fitoterapia 2008, 79,
21–23.
7. Khatun, M.H.;
Nesa, M.L.; Islam, R.; Ripa, F.A.; Kadir, S. Antidiabetic and antidiarrheal
effects of the methanolic extract of Phyllanthus
reticulatus leaves in mice. Asian Pacific J. Reprod. 2014, 3,
121–127.
8. Das, B.K.;
Bepary, S.; Datta, B.K.; Chowdhury, A.K.; Ali, M.S.; Rouf, A.S.S.
Hepatoprotective activity of Phyllanthus
reticulatus. Pak. J. Pharm. Sci. 2008, 21.
9. Omulokoli, E.;
Khan, B.; Chhabra, S.C. Antiplasmodial activity of four Kenyan medicinal
plants. J. Ethnopharmacol. 1997, 56, 133–137.
10. Das, B.K.; Shohel,
M.; Pavel, A.M.; Bhattacharjee, R.; Das, B.; Yasmin, T.; Akhter, N.; Hannan,
J.M.A. Anti hepatitis B viral activity of Phyllanthus
reticulatus. Bangladesh Pharm. J. 2011, 14, 11–14.
11. Tai, B.H.; Nhut,
N.D.; Nhiem, N.X.; Quang, T.H.; Thanh Ngan, N.T.; Thuy Luyen, B.T.; Huong,
T.T.; Wilson, J.; Beutler, J.A.; Ban, N.K. An evaluation of the RNase H
inhibitory effects of Vietnamese medicinal plant extracts and natural
compounds. Pharm. Biol. 2011, 49, 1046–1051.
12. Manjula, V.;
Norman, T.S.J. Skin healing activity of Naringi crenulata and Phyllanthus reticulatus. Pharma
Innov. 2017, 6, 376.
13. Neves, A.C.;
Neves, M.T.C. Some determinations on the leaves of Phyllanthus reticulatus Poir. of Mozambique. Bol Esc Farm Univ
Coimbra 1966, 25, 22.
14. Hui, W.-H.; Li,
M.-M.; Wong, K.-M. A new compound, 21α-hydroxyfriedel-4 (23)-en-3-one and other
triterpenoids from Phyllanthus
reticulatus. Phytochemistry 1976, 15, 797–798.
15. Joshi, K.C.;
Singh, P.; Mehra, A. Crystalline components of the roots of phyllanthus-reticulatus. J. Indian
Chem. Soc. 1981, 58, 102–103.
16. Lan, M.S.; Ma,
J.X.; Tan, C.H.; Wei, S.; Chen,
L.; Zhu, D.Y. Chemical constituents from Phyllanthus
reticulatus var. Glaber. Chinese Tradit. Herb. Drugs 2011, 42,
1712–1714.
17. Lam, S.; Wang, C.;
Chen, C.; Lee, S. Chemical investigation of Phyllanthus
reticulatus by HPLC‐SPE‐NMR and conventional methods. Phytochem. Anal.
An Int. J. Plant Chem. Biochem. Tech. 2007, 18, 251–255.
18. Lan, M.; Ma, J.;
Tan, C.; Wei, S.; Zhu, D. Chemical constituents of Phyllanthus reticulatus. Helv. Chim. Acta 2010, 93,
2276–2280.
19. Pojchaijongdee,
N.; Sotanaphun, U.; Limsirichaikul, S.; Poobrasert, O. Geraniinic acid
derivative from the leaves of Phyllanthus
reticulatus. Pharm. Biol. 2010, 48, 740–744.
20. Sangkasila, R.
Chemical constituents and some bioactivities of stem of Phyllanthus reticulatus Poir 1998.
21. Ma, J.-X.; Lan, M.-S.; Qu, S.-J.; Tan, J.-J.; Luo, H.-F.; Tan, C.-H.; Zhu, D.-Y. Arylnaphthalene lignan glycosides and other constituents from Phyllanthus reticulatus. J. Asian Nat. Prod. Res. 2012, 14, 1073–1077.
22. Engström, M. Understanding the bioactivity of plant tannins: developments in analysis methods and structure-activity studies. 2016.
This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Abstract
Phyllanthus
reticulatus Poir has long been used in the
traditional medications for the treatment of various human diseases most
notably diarrhoea, asthma, diabetes and inflammation. Several chromatographic techniques
were used to isolate the main active constituents from different parts of the
plants using different solvents. Over the last few decades, 57 compounds have
been isolated and identified from the P.
reticulatus including 12 terpenoids, 4 steroids, 7 flavonoids, 8
phenolics, 8 lignins, 8 tannins, 5 megastigmane glycosides, 3 diterpenoids, 1 purine derivative, 2 acid
deravetives and 1 fatty alcohol. This
review provided a comprehensive overview of the phytochemistry of P. reticulatus based
on the unified review of literature. The review suggests for further avenues of research on the phytochemistry of P. reticulatus to
isolate and decipher the unidentified lead compounds for future pharmaceutical applications.
Abstract Keywords
Friedelin, flavonoids, lignin megastigmane, Phyllanthus reticulatus, phytochemistry, terpenoids,
tannin, steroids.
This work is licensed under the
Creative Commons Attribution
4.0
License (CC BY-NC 4.0).
Editor-in-Chief
This work is licensed under the
Creative Commons Attribution 4.0
License.(CC BY-NC 4.0).